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Table 4 Clinical features of reassessed SLC35A2-MOGHE patients

From: Frequent SLC35A2 brain mosaicism in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE)

Patient ID

Sex

Age at seizure onset/age surgery

Seizure/epilepsy types

MRI findings (3T)

Resection topology

Outcome (Engel score)

Follow up after surgery (m)

Previous reports

FR-1

M

1y6m/3y

IS

L frontal extensive FCD

Left frontal

I

30

[2]

FR-2

M

7m/4y

IS

R temporal FCD

Right multilobar

III

33

[2]

FR-3

M

2y6m/8y

IS

L temporo-occipital FCD

Left multilobar

I

9

[2]

FR-4

M

5m/3y

IS

R frontal extensive FCD

Right multilobar

I

15

[2]

FR-5

F

6m/13y

IS, LGS

L fronto-basal FCD

Left multilobar

I

12

Unpublished

KR-1

M

3m/3y5m

IS, LGS

MRI-negative*

Right multilobar

IV

49

[38]

KR-2

M

3m/5y2m

IS, LGS

MRI-negative*

Left multilobar

I

75

[38]

KR-3

F

13m/5y1m

IS, LGS

MRI-negative*

Left multilobar

I

69

[38]

KR-4

M

3y2m/6y3m

IS, LGS

MRI-negative*

Left multilobar

I

57

[38]

KR-5

F

5m/4y

IS, LGS, MS

R frontal FCD

Right multilobar

I

32

[38]

KR-6

M

7m/2y8m

IS, LGS

R temporo-parietal increase white matter signal in T2

Right parietal

I

26

[38]

KR-7

M

6m/2y1m

IS

MRI-negative*

Right multilobar

I

48

[39]

KR-8

M

2y6m/6y1m

LGS

Left frontal FCD

Left frontal

I

30

[39]

KR-9

F

10m/10y2m

LGS

MRI-negative*

Left multilobar

IV

30

[39]

KR-10

F

6m/9y

IS, LGS

MRI-negative*

Right temporal

I

11

Unpublished

NL-1

M

NA/5y

Focal to bilateral TCS

MRI-negative*

Left occipital

I

24

Unpublished

NL-2

F

NA/1y

IS

L extensive cortical malformation

Left frontal

I

12

Unpublished

  1. F female, M male, IS infantile spasms, TS tonic seizures, MS myoclonic seizures, LGS Lennox-Gastaut syndrome, TCS tonic–clonic seizures, L left, R right, FCD focal cortical dysplasia, NA not available
  2. *Different MRI protocols were used among the centers, therefore MRI-negative cases should be interpreted with caution