Skip to main content

Table 1 Control and PD case demographics

From: Neuroinflammation and protein pathology in Parkinson’s disease dementia

  Control PDND PDD p value
N 14 17 11
Postmortem interval (h) 64.1 (± 38.3) 58.8 (± 28.1) 61.5 (± 32.7) 0.903
Sex: % Male 64.3% 51.9% 90.9% 0.112
Age at death 79.8 (± 5.9) 79.0 (± 8.1) 81.8 (± 6.4) 0.573
Age at diagnosis 66.9 (± 11.1) 67.9 (± 9.7) 0.803
Disease duration at death (yr) 12.1 (± 4.8) 13.9 (± 6.4) 0.396
Interval from last assessment to death (yr) 4.2 (± 3.3) 3.9 (± 4.1) 0.749
Last Hoehn and Yahr score 2.6 (± 0.7) 2.9 (± 0.8) 0.693
Last UPDRS motor (on medication) 30.6 (± 15.0) 39.3 (± 9.9) 0.117
Last UPDRS total (on medication) 50.2 (± 21.3) 69.8 (± 16.9) 0.021*
Last MMSE 28.7 (± 1.2) 20.6 (± 5.1) < 0.0001****
Change in MMSE per year 0.21 (± 0.64) − 1.46 (± 1.34) < 0.0001****
  1. Continuous variables were compared using One-way ANOVA (between Control, PDND and PDD) or Mann–Whitney U test (between PDND and PDD). Categorical variables (sex) were compared using the χ2 test. UPDRS Unified Parkinson’s Disease Rating Scale, MMSE Mini-Mental State Examination, PDND Parkinson's disease no dementia, PDD Parkinson's disease dementia. The values represent the mean (± SD)
  2. *p < 0.05, ****p < 0.0001