Fig. 5

YAP1 fusions induce brain tumors with different morphological and histologic features from RELA^FUS-induced tumors in mice (a and b) Kaplan–Meier survival curves and Summary of YAP1 fusion-induced brain tumors. Lentiviruses were injected into neonatal pups brain in Nestin-Cre^+/−;Cag-Cas9^+/+ mice. For comparison, the survival curve of RELA^FUS1-induced tumors as shown in Fig. 1a was depicted in the figure (n.s., not significant, **p < 0.01. M, medium titer; n/a, not applicable). c Representative H&E and IHC stains for HA tag, YAP1 and GFAP antibodies of the HA-YAP1-FAM118B-induced brain tumor in Nestin-Cre^+/−;Cag-Cas9^+/+ mice (n = 3)