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Table 2 Univariable and multivariable Cox regression analysis for survival (n = 557)

From: TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations

 

n

Univariable

Multivariable

HR

95% C.I.

p value

HR

95% C.I.

p value

Sex

 M

315

0.832

0.592–1.169

0.289

1.076

0.759–1.527

0.680

 F

242

Ref

  

Ref

  

Age

 − 50

397

Ref

  

Ref

  

 > 50

160

1.361

0.945–1.960

0.098

1.555

1.051–2.300

0.027

KPS

 90–100

459

Ref

  

Ref

  

 < 90

98

2.833

1.971–4.074

< 0.0001

1.706

1.136–2.562

0.010

WHO gradea

 II

285

Ref

  

Ref

  

 III

239

1.167

0.808–1.687

0.410

1.198

0.778–1.845

0.413

 IV

33

8.646

5.135–14.558

< 0.0001

5.761

2.978–11.145

< 0.0001

TERT

 wt

255

Ref

  

Ref

  

 mut

302

0.278

0.191–0.404

< 0.0001

0.421

0.178–0.998

0.0494

1p/19q

 Non-codel

273

Ref

  

Ref

  

 Codel

284

0.286

0.195–0.419

< 0.0001

0.648

0.262–1.604

0.349

RT

 (−)

240

Ref

  

Ref

  

 (+)

317

1.555

1.084–2.232

0.017

0.847

0.531–1.349

0.484

Chemo

 (−)

179

Ref

  

Ref

  

 (+)

378

1.252

0.857–1.829

0.246

1.299

0.769–2.196

0.329

EOR

 90–100%

326

0.487

0.346–0.685

< 0.0001

0.513

0.359–0.735

0.0003

 < 90%

231

Ref

  

Ref

  
  1. Chemo, Chemotherapy; C.I., Coefficient interval; codel, codeleted; EOR, extent of resection; F, female; HR, hazard ratio; KPS, Karnofsky Performance Status; M, male; mut, mutant; Ref, Reference; RT, radiation therapy; wt, wild-type
  2. aDiagnosis based on CNS WHO2016
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Acta Neuropathologica Communications

ISSN: 2051-5960

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