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Table 1 Patient characteristics (n = 560)

From: TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations

IDH

All

mut

mut

mut

mut

TERT

mut

mut

wt

wt

1p/19q

codel

intact

codel

intact

Total (n)

560

279

24

6

251

Mean age (y.o.)

43.5

46.4

41.8

48.2

40.3

 − 50

399

178

18

3

200

 > 50

161

101

6

3

51

M/F

317/243

162/117

14/10

5/1

136/115

WHO gradea

 II

287

145

13

4

125

 III

240

134

6

2

98

 IV

33

0

5

0

28

Integrated diagnosisa

 DA

138

0

13

0

125

 AA

104

0

6

0

98

 OL

149

145

0

4

0

 AO

136

134

0

2

0

 GBM

33

0

5

0

28

KPS

 90–100

460

238

20

6

196

 < 90

98

41

4

0

53

 nd

2

0

0

0

2

Location

 Supratentorial

557

279

24

6

248

 Infratentorial

3

0

0

0

3

CDKN2A

 Homo Del

19

3

1

1

14

 Non-Del

365

187

17

3

158

 nd

176

89

6

2

79

RT

 (+)

318

137

17

3

161

 (−)

241

141

7

3

90

 nd

1

1

0

0

0

Chemo

 (+)

379

210

16

3

150

 (−)

180

68

8

3

101

 nd

1

1

0

0

0

EOR

 90–100%

329

179

15

2

133

 < 90%

231

100

9

4

118

  1. AA, anaplastic astrocytoma, IDH-mutant; AO, anaplastic oligodendroglioma, IDH-mutant and 1p/19q-codeleted; Chemo, Chemotherapy; codel, codeleted; DA, diffuse astrocytoma, IDH-mutant; Del, Deletion; EOR, extent of resection; F, female; GBM, glioblastoma, IDH-mutant; Homo, Homozygous; nd, no data; KPS, Karnofsky Performance Status; M, male; mut, mutated; OL, oligodendrolioma, IDH-mutant and 1p/19q-codeleted; RT, radiation therapy; y.o., years old; wt, wild-type
  2. aDiagnosis based on CNS WHO2016