Fig. 7
From: Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques
Overexpression of CLAC-P significantly increased the number of ubiquitin-positive neuritic plaques. a–d Immunohistochemical analyses of the brains of 15-month-old APP tg mice (J20 line, a and c) and double tg mice (b and d) using an anti-human Aβ antibody (BAN50) (a and b) and an anti-ubiquitin antibody (c and d). High magnification images (insets in b and d) were shown in e and f, respectively. A part of both Aβ and ubiquitin positive plaques were highlighted (arrows). Scale bar shows 200 μm (a–d) and 50 μm (e and f). g The mean number of ubiquitin-positive plaques was assessed in the hippocampus of 15-month-old APP tg mice (blue, N = 6) and double tg mice (red, N = 7). Mann–Whitney U test, p = 0.0066