Fig. 5

iTTBK1 Tg mice exhibit dramatic Purkinje cell loss. a, b Representative low-power images of CaB immunostaining in the cerebellum of control and iTTBK1 Tg animals. iTTBK1 Tg animals demonstrate wide scale Purkinje cell loss throughout the cerebellar lobules. Arrows indicate the cerebellar lobule depicted at higher power in c and d where Purkinje cell number was quantified (e). ***p < 0.0001 by two-tailed t test. Scale Bar = 500 μm (a, b) and 100 μm (c, d)