Fig. 1From: Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in miceiTTBK1 Tg mice express high levels of human TTBK1. a Schematic of mouse transgene regulation. b–k Immunohistochemistry using an α-TTBK1 antibody raised against the C-terminus of the protein. Human TTBK1 is highly expressed in the adult mouse brain following induction of the iTTBK1 transgene. b, d, f, h, j Tissue from control mice. c, e, g, i, k Tissue from iTTBK1 Tg mice. Scale Bar = 500 µm. b, c Forebrain, d, e Hippocampus, f, g Brainstem, h, l Cerebellum, j, k Spinal cord. l Immunoblot of TTBK1 expression from control or iTTBK1 Tg whole brain lysateBack to article page