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Table 2 Mendelian randomization results for the causal role of α-Syn, Aβ42, tau, and t-tau in Parkinson’s disease using the robust regression MR-Egger method with robust regression

From: Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease

Biomarker PD Risk1 PD age at Onset2
Effect P-value Effect P-value
Alpha-synuclein − 1.389 0.064 − 11.018 0.835
Amyloid-beta 0.430 1.44 × 10−05 7.746 7.65 × 10−06
Total tau − 0.338 0.246 11.276 0.069
Phosphorylated tau − 0.096 0.785 − 0.298 0.912