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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease

Fig. 5

APOE ε4 is associated with Aβ42 deposition in the brains of Parkinson’s disease individuals. a Comparison of the levels of CSF Aβ42 in control (N = 26) and PD (N = 108) participants stratified by the presence (ε4 + ; green) or absence (ε4-; blue) of the APOE ε4 allele. b Effect of APOE ε4 allele on the levels of mean cortical binding potentials (MCBP) in controls (N = 44) and Parkinson’s disease (N = 156). c PD patients carrying the APOE ε4 allele exhibit a higher Braak Aβ score than non-carriers (N = 92). Differences between APOE ε4 carriers and non-carriers were statistically significant by the Mann–Whitney U test

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