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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease

Fig. 3

Genetic architecture correlations of Parkinson’s disease risk with CSF α-Syn, t-tau, p-tau181 and Aβ42 levels. PRSice bar plots for Parkinson’s disease risk and CSF biomarkers. Nagelkerke pseudo-R-squared fit for the model of a CSF α-Syn levels PRS and Parkinson’s disease risk. b CSF t-tau levels PRS and Parkinson’s disease risk. c CSF p-tau181 PRS and Parkinson’s disease risk. d CSF Aβ42 levels PRS and Parkinson’s disease risk. Total variance explained by the PRS for multiple p-value thresholds for the inclusion of SNPs, with the red bar indicating the optimal p-value threshold (PT), explaining the maximum amount of variance (R2) in Parkinson’s disease risk in the target sample

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