Fig. 2
Association plot of single variant analyses of CSF α-Syn, t-tau, p-tau181 and Aβ42 levels. Manhattan plot shows negative log10-transformed p-values from the meta-analysis of a α-Syn. b total tau. c phosphorylated tau and d Aβ42 CSF levels. The lowest p-value on chr19 (APOE locus) was p = 4.5 × 10−43. The horizontal lines represent the genome-wide significance threshold, p = 5×10−8 (red) and suggestive threshold, p = 1×10−5 (blue). e, f Regional association plots of loci are shown for SNPs associated with CSF Aβ42 levels near HLA (e) and near APOE locus (f). The SNPs labeled on each regional plot had the lowest p-value at each locus and are represented by a purple diamond. Each dot represents an SNP, and dot colors indicate linkage disequilibrium with the labeled SNP. Blue vertical lines show the recombination rate marked on the right-hand y-axis of each regional plot. Suggestive SNPs for α-Syn, t-tau, p-tau181 can be found in Additional file 2: Tables S3 to S6