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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Microembolus clearance through angiophagy is an auxiliary mechanism preserving tissue perfusion in the rat brain

Fig. 6

Microspheres induce BBB opening in vivo. a There was widespread IgG extravasation (white) throughout the injected hemisphere, whereas this was not the case in the control hemisphere. Scale bar = 1 mm. b Quantification of IgG signal intensity at D1, 3 and 7 in the control (dark grey) and injected (light grey) hemispheres. N = 6–7 animals per time point. Data are depicted as median and IQR (min–max). *P < 0.05, between hemispheres, Wilcoxon matched-pairs signed rank test; #,$P < 0.05, D1 versus D7 and D3 versus D7, Kruskal–Wallis with Dunn’s multiple comparison test. c Accumulation of IgG was occasionally observed at places where microspheres had lodged (boxed regions in left overview image are enlarged in the right panel, microspheres are indicated by red arrows). d Width of control and treated hemispheres were measured in ex vivo coronal sections and quantification demonstrated that the treated hemisphere (light grey) expanded at the expense of the control hemisphere (dark grey). N = 6–7 animals per time point. Data are depicted as median and IQR (min–max). *P < 0.05, **P < 0.01, between hemispheres, paired t test

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