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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Is the eye a window to the brain in Sanfilippo syndrome?

Fig. 8

AAV9-CMV-SGSH (or control vector) was delivered i.v. to mice on each of day 0 and day 5 of life and the impact on substrate accumulation in the endo/lysosomal compartment in mouse retina and brain was determined 6 weeks post-injection. % LIMP2 immunoreactivity was evaluated in the retina (a), rostral cortex (b), medial cortex (c), thalamus (d), inferior colliculus (e) and brainstem (f). Accumulation of primary substrate (heparan sulphate) in brain slice 2, 4 and 5 is shown in gi). The 2 mm thick brain slice protocol is shown in j. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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