Fig. 6
From: Is the eye a window to the brain in Sanfilippo syndrome?
Analysis of GFAP-immunoreactivity in three to 25 week old unaffected and MPS IIIA mouse retina, optic nerve and brain. Representative images of GFAP immunolabelling in 25 week old unaffected and MPS IIIA mouse retina (a, b), optic nerve (d, e), visual cortex (g, h) and superior colliculus (j, k). Scale bar = 50 µm. Quantification of % GFAP immunoreactivity in the retina (c), optic nerve (f) visual cortex (i) and superior colliculus (l) revealed elevated GFAP expression in all MPS IIIA tissues except optic nerve. Data are mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001