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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Is the eye a window to the brain in Sanfilippo syndrome?

Fig. 5

Evaluation of microglial activation in three to 25 week old unaffected and MPS IIIA mouse retina, optic nerve and brain. Representative images of isolectin-B4 staining in 25 week old unaffected and MPS IIIA mouse retina (a, b), optic nerve (d, e), visual cortex (g, h) and superior colliculus (j, k). Insets show higher-power images of ameboid, presumptively activated microglial cells in MPS IIIA mouse tissues. Scale bar = 50 µm. Quantification of activated microglia in the retina (c), optic nerve (f), visual cortex (i) and superior colliculus (l) revealed elevated numbers of activated microglia in all tissues in MPS IIIA mice from 3 weeks of age. Data are mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001

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