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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Is the eye a window to the brain in Sanfilippo syndrome?

Fig. 4

Analysis of endo/lysosomal compartment expansion in unaffected and MPS IIIA mouse retina, optic nerve, and brain. Quantification of stored heparan sulphate in the retina (a), optic nerve (b) and whole brain (c) in three to 25 week old mice. Representative images of LIMP2 immunolabelling in 25 week old unaffected and MPS IIIA mouse retina (d, e), optic nerve (g, h), visual cortex (j, k) and superior colliculus (m, n). Quantification of % LIMP2 immunoreactivity in the retina (f), optic nerve (i), visual cortex (l) and superior colliculus (o). Scale bar; d, e, g, h, j, k, m, n = 50 µm. Data are expressed as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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