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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Is the eye a window to the brain in Sanfilippo syndrome?

Fig. 2

Evaluation of the inner and outer segments in three to 25 week old unaffected and MPS IIIA mice. Haematoxylin and eosin-stained retina showing the photoreceptor segment (PS) layer (a), magnified in (b) to delineate inner (IS) and outer (OS) segments. Quantification of inner (c) and outer (d) segment length in central and peripheral retina. eh Representative images of rhodopsin immunostaining detailing rod outer segments in 6 and 25 week old unaffected and MPS IIIA mouse central retina. Peanut agglutin (PNA)-stained cone segments in 25 week old unaffected (i) and MPS IIIA (j) central retina. k Quantification of the number of PNA-stained inner segments. Scale bar; a = 25 µm; b = 5 µm; eh = 20 µm; i, j = 10 µm. Data are expressed as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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