Fig. 3
From: Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology
Aβ pathology increases microglia clustering around Aβ plaques. a Representative images of Iba1 (in green) and CD68 (in red) staining of microglia in the ipsilateral dentate gyrus in WT/AAV-tau and 5xFAD/AAV-tau mice. DAPI staining is shown in blue. Scale bars: 100 µm (upper panels); 25 µm (lower panels). b, c Percentage of the hippocampal area covered by Iba1 (b) and CD68 (c) staining. Note the significant effect of the Aβ on the density of microglial cells. Statistical analysis: unpaired two-tailed Student’s t-test, ****p < 0.0001; WT/AAV-tau: n = 12 mice, 5xFAD/AAV-tau: n = 15 mice