Fig. 2
From: Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology
Overexpression of human tau leads to degeneration in the dentate gyrus and increases Aβ deposition in female 5xFAD mice. a Representative images of the ipsilateral hippocampus of 5xFAD mice injected with either AAV-tau or the AAV-GFP control vector. Note the degeneration of the dentate gyrus (DG) polymorphic layer and the thinning of the granular layer (white arrowhead) in the hippocampus injected with AAV-tau, in contrast to the hippocampus injected with AAV-GFP (*). DAPI staining in grey. Scale bar: 500 µm. b Measured ipsi/contralateral ratio of the DG area showing the effects of AAV-tau on DG degeneration in 5xFAD mice. Note the significant degeneration of the DG induced by AAV-tau injection. c Ipsi/contralateral ratio of the DG area comparing WT and 5xFAD littermate mice injected with AAV-tau. d Percentage of the ipsi- and contralateral hippocampus covered by Aβ deposits (4G8 staining) in 5xFAD/AAV-GFP and 5xFAD/AAV-tau mice. All mice are included in the analysis. e Percentage of the total hippocampus area covered by Aβ deposits (4G8 staining) comparing female mice only. Note the significant effect of AAV-tau on Aβ deposition in female mice. Statistical analysis: two-way ANOVA (d) and unpaired two-tailed Student’s t-test (b, c and e), *p < 0.05 and ****p < 0.0001; 5xFAD/AAV-GFP: n = 15 mice including 10 females, 5xFAD/AAV-tau: n = 15 mice, including 8 females, WT/AAV-tau: n = 13 mice