Fig. 7
From: In vivo RyR1 reduction in muscle triggers a core-like myopathy
Autophagy is inhibited in RyR1-Rec D75 mice quadriceps muscle. a, c Representative Western blot on 4 CTRL and 4 RyR-Rec quadriceps muscle homogenates. b Quantification of the amount of protein normalized to the amount of GAPDH in 8–12 mice in each group (CTRL, black bars; RyR1-Rec, blue bars). For S6 and mTOR, the values are presented as ratio of the phosphorylated/non-phosphorylated protein. The value for each animal is the mean of at least 3 blots. All the data are presented as mean ± SEM. The mean value in the CTRL group was set to 1 for each protein. Statistical analysis: t test with Holm-Sidak method for multiple comparisons