Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis

Lasolle, Hélène; Elsensohn, Mad-Hélénie; Wierinckx, Anne; Alix, Eudeline; Bonnefille, Clément; Vasiljevic, Alexandre; Cortet, Christine; Decoudier, Bénédicte; Sturm, Nathalie; Gaillard, Stephan; Ferrière, Amandine; Roy, Pascal; Jouanneau, Emmanuel; Bertolino, Philippe; Bardel, Claire; Sanlaville, Damien; Raverot, Gérald

doi:10.1186/s40478-020-01067-5

Acta Neuropathologica Communications

Table 3 List of genes associated with recurrence in lactotroph tumors selected using CGH array (univariate and multivariate analysis) and transcriptomic analysis

From: Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis

Gene	Chromosome	aCGH univariate logistic regressions		aCGH multivariate logistic regressions^b		Transcriptomic analysis
Gene	Chromosome	LRT raw p-values	LRT adjusted p-values^a	LRT raw p-values	LRT adjusted p-values^a	Fold-Change	T-test p-values
*ACTL8*	1	0.003	0.041	0.003	0.046	10.955	0.004
ALDH3B1	11	0.005	0.041	0.012	0.099	2.194	0.033
*AMBRA1*	11	0.002	0.041	0.002	0.046	3.642	0.033
*ATPAF1*	1	0.005	0.041	0.003	0.046	− 2.104	0.016
*CEL*	9	0.001	0.041	0.003	0.046	2.392	0.004
*CLCNKA*	1	0.003	0.041	0.003	0.046	9.043	0.012
DLG2	11	0.005	0.041	0.012	0.099	− 2.146	0.027
*DOCK7*	1	0.005	0.041	0.003	0.046	2.100	0.000
DPAGT1	11	0.005	0.041	0.012	0.099	6.217	0.001
*ELAVL4*	1	0.005	0.041	0.003	0.046	2.786	0.039
*FPGT-TNNI3K*	1	0.003	0.041	0.003	0.046	2.064	0.036
FRMD8	11	0.005	0.041	0.012	0.099	25.132	0.007
*GSTM4*	1	0.003	0.041	0.003	0.046	19.111	0.019
*HECTD3*	1	0.005	0.041	0.003	0.046	2.465	0.002
*HMGCL*	1	0.001	0.041	0.003	0.046	− 2.135	0.017
*HSD17B12*	11	0.002	0.041	0.002	0.046	− 2.021	0.016
*HSPB7*	1	0.003	0.041	0.003	0.046	10.999	0.012
*HTATIP2*	11	0.002	0.041	0.002	0.046	− 2.014	0.008
KCNJ5	11	0.005	0.041	0.012	0.099	− 2.514	0.002
*LAPTM5*	1	0.003	0.041	0.003	0.046	− 2.272	0.034
*LPL*	8	0.000	0.041	0.001	0.046	2.578	0.003
*MAST2*	1	0.005	0.041	0.003	0.046	2.094	0.023
*MDK*	11	0.002	0.041	0.002	0.046	− 2.180	0.041
*NRIP3*	11	0.002	0.041	0.002	0.046	2.076	0.020
*PAMR1*	11	0.002	0.041	0.002	0.046	− 2.563	0.048
PGM2L1	11	0.005	0.041	0.012	0.099	2.222	0.013
PHOX2A	11	0.005	0.041	0.012	0.099	52.058	0.007
*PIFO*	1	0.003	0.041	0.003	0.046	2.751	0.001
*PLA2G2F*	1	0.003	0.041	0.003	0.046	3.403	0.047
*POMGNT1*	1	0.005	0.041	0.003	0.046	15.479	0.047
*PRKAA2*	1	0.005	0.041	0.003	0.046	2.568	0.002
*RHCE*	1	0.003	0.041	0.003	0.046	− 2.184	0.017
RPUSD4	11	0.005	0.041	0.012	0.099	2.011	0.001
*RUNX3*	1	0.003	0.041	0.003	0.046	− 2.438	0.003
SCGB1D2	11	0.005	0.041	0.012	0.099	2.155	0.005
*SOX6*	11	0.001	0.041	0.001	0.046	37.554	0.000
SRSF8	11	0.005	0.041	0.012	0.099	− 2.223	0.010
*ST3GAL3*	1	0.005	0.041	0.003	0.046	11.519	0.000
*TARDBP*	1	0.003	0.041	0.003	0.046	2.117	0.001
TMEM216	11	0.005	0.041	0.012	0.099	− 2.006	0.009

Bold character correspond to significant adjusted p-values of aCGH multivariate logistic regressions
LRT likelihood ratio test
^aBenjamini-Hochberg
^aAdjusted for age at diagnosis, sex, histologic grade

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