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Table 2 Comparison of altered versus non-altered tumors

From: Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis

  Alterations No alterations
Gonadotroph 24 32
 Age 54.19 (14.1) 54 (14.1)
 Sex   
  F 10 (41.7%) 11 (34.4%)
  M 14 (58.3%) 21 (65.6%)
 Recurrence   
  Yes 15 (62.5%) 18 (56.3%)
  No 9 (37.5%) 14 (43.7%)
 Grade   
  1a 7 (29.2%) 11 (34.4%)
  1b 1 (4.2%) 1 (3.1%)
 2a 12 (50.0%) 16 (50%)
  2b 4 (16.6%) 4 (12.5%)
 Size   
  Microadenomas 0 (0%) 0 (0%)
  Macroadenomas 24 (100%) 31 (96.9%)
  Giant Adenomas 0 (0%) 1 (3.1%)
 Secretion   
  Silent 24 (100%) 32 (100%)
  Functioning 0 (0%) 0 (0%)
Immunonegative 2 9
 Age 52.49 (7.5) 58.36 (11.6)
 Sex   
  F 1 (50%) 3 (33.3%)
  M 1 (50%) 6 (66.7%)
 Recurrence   
  Yes 1 (50%) 4 (44.4%)
  No 1 (50%) 5 (55.6%)
 Grade   
  1a 0 (0%) 2 (22.2%)
  1b 0 (0%) 1 (11.1%)
  2a 2 (100%) 6 (66.7%)
  2b 0 (0%) 0 (0%)
 Size   
  Microadenomas 0 (0%) 0 (0%)
  Macroadenomas 2 (100%) 8 (88.9%)
  Giant Adenomas 0 (0%) 1 (11.1%)
 Secretion   
  Silent 2 (100%) 9 (100%)
  Functioning 0 (0%) 0 (0%)
Somatotroph 37 19
 Age 44.36 (12.9) 41.84 (10.8)
 Sex   
  F 18 (48.7%) 12 (63.2%)
  M 19 (51.3%) 7 (36.8%)
 Recurrence   
  Yes 23 (62.2%) 17 (89.5%)
  No 14 (37.8%) 2 (10.5%)
 Grade   
  1a 12 (32.4%) 4 (21.1%)
  1b 2 (5.4%) 0 (0%)
  2a 16 (43.3%) 10 (52.6%)
  2b 7 (18.9%) 5 (26.3%)
 Size   
  Microadenomas 3 (8.1%) 1 (5.6%)
  Macroadenomas 33 (89.2%) 17 (94.4%)
  Giant Adenomas 1 (2.7%) 0 (0%)
 GNAS   
  WT 25 (67.6%) 15 (78.9%)
  Mutation 10 (27.0%) 3 (15.8%)
  Not available 2 (5.4%) 1 (5.3%)
 Secretion   
  Silent 0 (0%) 4 (21.1%)
  Functioning 37 (100%) 15 (78.9%)
Lactrotroph 34 5
 Age 42.06 (14.7) 40.1 (6.9)
 Sex   
  F 11 (32.4%) 2 (40.0%)
  M 23 (67.6%) 3 (60.0%)
 Recurrence   
  Yes 27 (79.4%) 1 (20.0%)
  No 7 (20.6%) 4 (80.0%)
 Grade   
  1a 9 (26.5%) 1 (20.0%)
  1b 2 (5.9%) 1 (20.0%)
  2a 12 (35.3%) 1 (20.0%)
  2b 11 (32.3%) 2 (40.0%)
 Size   
  Microadenomas 1 (2.9%) 1 (20.0%)
  Macroadenomas 28 (82.4%) 4 (80.0%)
  Giant Adenomas 5 (14.7%) 0 (0.0%)
 Secretion   
  Silent 2 (5.9%) 0 (0%)
  Functioning 32 (94.1%) 5 (100%)
Corticotroph 24 9
 Age 45.99 (12.0) 39.37 (18.7)
 Sex   
  F 11 (45.8%) 5 (55.6%)
  M 13 (54.2%) 4 (44.4%)
 Recurrence   
  Yes 13 (54.2%) 5 (55.6%)
  No 11 (45.8%) 4 (44.4%)
 Grade   
  1a 12 (50.0%) 4 (44.5%)
  1b 1 (4.2%) 0 (0.0%)
  2a 11 (45.8%) 3 (33.3%)
  2b 0 (0%) 2 (22.2%)
 Size   
  Microadenomas 5 (20.8%) 2 (22.2%)
  Macroadenomas 19 (79.2%) 7 (77.8%)
  Giant Adenomas 0 (0.0%) 0 (0.0%)
 Secretion   
  Silent 5 (20.8%) 3 (33.3%)
  Functioning 19 (79.2%) 6 (66.7%)
 USP8   
  WT 17 (70.8%) 5 (55.6%)
  Mutation 4 (16.7%) 1 (11.1%)
  Not available 3 (12.5%) 3 (33.3%)