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Table 1 Differentially expressed genes comparing prefrontal cortex in response to cisplatin

From: Bexarotene normalizes chemotherapy-induced myelin decompaction and reverses cognitive and sensorimotor deficits in mice

Gene

log2FoldChange

Padj

Upregulated genes

 Cdh1

1.281674

9.94E−05

 Hba-a2

1.233547

0.05081

 Slc47a1

1.145545

0.004625

 Gm42047

0.780093

0.027633

 Prg4

0.757131

0.009389

 Fmod

0.528089

1.30E−06

 Rsph10b

0.457828

0.098236

 Islr

0.423915

0.079967

 Slc13a4

0.421721

0.086691

 Hsd11b1

0.372621

0.086691

 Ptgds

0.354773

0.001266

 Slc26a2

0.310505

0.068721

 Uvssa

0.280211

0.098236

 Cxcl12

0.237664

0.086691

Downregulated genes

 Lcn2

− 3.75254

0.003447

 Capn11

− 3.04156

0.007803

 Ifitm1

− 0.83312

0.082431

 Hspa1a

− 0.70256

0.003447

 mt-Ti

− 0.51871

0.027633

 Xdh

− 0.44559

0.060968

 Dusp1

− 0.38506

0.086691

 Dusp5

− 0.3716

0.086691

 Tbc1d4

− 0.30415

0.019153

 Mal

− 0.28939

0.079967

 Fam107a

− 0.28644

0.086691

 Bc1

− 0.26192

0.009824

 Nr1d1

− 0.2582

0.009796

  1. Mice were treated with cisplatin (two rounds of 5 daily injections of 2.3 mg/kg with 5 days of rest in between) or PBS and prefrontal cortex was collected 5 days after the last dose of cisplatin. Data represent genes differentially expressed genes with padj < 0.1. Genes identified in italic are involved in myelin formation/maintenance
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Acta Neuropathologica Communications

ISSN: 2051-5960

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