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Table 1 Differentially expressed genes comparing prefrontal cortex in response to cisplatin

From: Bexarotene normalizes chemotherapy-induced myelin decompaction and reverses cognitive and sensorimotor deficits in mice

Gene log2FoldChange Padj
Upregulated genes
 Cdh1 1.281674 9.94E−05
 Hba-a2 1.233547 0.05081
 Slc47a1 1.145545 0.004625
 Gm42047 0.780093 0.027633
 Prg4 0.757131 0.009389
 Fmod 0.528089 1.30E−06
 Rsph10b 0.457828 0.098236
 Islr 0.423915 0.079967
 Slc13a4 0.421721 0.086691
 Hsd11b1 0.372621 0.086691
 Ptgds 0.354773 0.001266
 Slc26a2 0.310505 0.068721
 Uvssa 0.280211 0.098236
 Cxcl12 0.237664 0.086691
Downregulated genes
 Lcn2 − 3.75254 0.003447
 Capn11 − 3.04156 0.007803
 Ifitm1 − 0.83312 0.082431
 Hspa1a − 0.70256 0.003447
 mt-Ti − 0.51871 0.027633
 Xdh − 0.44559 0.060968
 Dusp1 − 0.38506 0.086691
 Dusp5 − 0.3716 0.086691
 Tbc1d4 − 0.30415 0.019153
 Mal − 0.28939 0.079967
 Fam107a − 0.28644 0.086691
 Bc1 − 0.26192 0.009824
 Nr1d1 − 0.2582 0.009796
  1. Mice were treated with cisplatin (two rounds of 5 daily injections of 2.3 mg/kg with 5 days of rest in between) or PBS and prefrontal cortex was collected 5 days after the last dose of cisplatin. Data represent genes differentially expressed genes with padj < 0.1. Genes identified in italic are involved in myelin formation/maintenance