Table 1 Clinical and tumor characteristics
Characteristics | Number of patients (%) |
|---|---|
Age (years), mean ± SD | 58.3 ± 9.5 |
Sex | |
Female | 22 (42.3%) |
Male | 30 (57.7%) |
Surgery | |
Biopsy | 20 (38.4%) |
Resection | 32 (61.6%) |
Karnofsky performance score | |
≥ 80% | 45 (86.5%) |
≥ 70 to < 80% | 6 (11.5%) |
< 70% | 1 (2%) |
Tumor Characteristics | |
Volume at baseline, mean ± SD | |
T1-weighted with Gadolinium W/necrosis | 31.1 cm3 ± 28.6 |
T1-weighted with Gadolinium W/O necrosis | 18 cm3 ± 16.5 |
Necrosis part, mean (%) | 33% [min. 0–max. 87%] |
Flair | 114.9 cm3 ± 63.2 |
Histology | |
Glioblastoma-IDH wild type | 46 (88.4%) |
Glioblastoma IDH-mutated | 3 (5.8%) |
Gliosarcoma | 3 (5.8%) |
MGMTp methylation | |
Non-methylated | 26 (50%) |
Low methylation profile | 2 (4%) |
Methylated | 12 (23%) |
Unknown | 12 (23%) |
TERTp mutation | |
C228T | 44 (84.6%) |
C250T | 1 (1.9%) |
Wild-type (wt) | 6 (11.6%) |
Unknown | 1 (1.9%) |