Fig. 4

Patient (#059) with TERTp C228T gliosarcoma and TERTp detection in plasma at diagnosis. Patient #059 was a 64-year-old man suffering from frontal C228T TERTp, IDH wild-type gliosarcoma spreading into the corpus callosum. a The lesion was predominantly necrotic: 43 cm³ of T1-weighted gadolinium volume with necrosis versus 11 cm³ without necrosis; the percentage of necrosis was 74%. In contrast, the rest of the cohort had an average rate of necrosis of 33%. The T2-FLAIR volume was also consequential, with a total volume of 184 cm³. b Circulating C228T TERTp mutation was detected both pre- and postoperatively. Two assays were performed (assay 1 and 2). The presented results are the mean of the two assays, with error bar (± standard deviation). c The kinetics of cfDNA concentration correlated with ctDNA MAF and decreased after tumor resection