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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: EZHIP is a specific diagnostic biomarker for posterior fossa ependymomas, group PFA and diffuse midline gliomas H3-WT with EZHIP overexpression

Fig. 2

EZHIP expression in ependymomas. The first line shows immunohistochemical analyses of a case of PFA-EPN exhibiting a loss of H3K27me3 (A, magnification, ×170), no H3K27-mutant protein (B, magnification, ×170) and an EZHIP overexpression with a strong and diffuse nuclear staining (C, magnification, ×170). The second line represents a case of PFB-EPN with, as expected, no loss of H3K27me3 expression (D, magnification, ×170), no H3K27-mutant protein expression (E, magnification, ×170), and negative EZHIP immunostaining (F, magnification, ×170). The last case (line 3) corresponds to a variant of PFA-EPN with H3K27-mutation exhibiting an H3K27me3 loss (G, magnification, ×170), a strong positive staining for H3K27-mutant protein (H, magnification, ×170) and no EZHIP expression (I, magnification, ×170). Black scale bars represent 250 μm

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