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Table 4 Summary of colocalization coefficient values from all evaluated brain regions of the FTLD-TDP cases

From: Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions

Brain regions Coefficients Molecules immunolabeled with ATXN2
Calnexin RPS6 LAMP1 GLG1 PABP1 TDP-43
Temporal cortex PCC 0.4075 0.7336# − 0.2568 0.1767 0.6783# 0.0027
  (SD) 0.1026 0.0293 0.0715 0.1448 0.1207 0.2457
  tM 0.7545* 0.9126** 0.3935 0.5475 0.872** 0.4817
  (SD) 0.1427 0.0640 0.0560 0.2057 0.0209 0.1394
Hippocampal CA1 PCC 0.4421 0.6949# 0.1620 0.0542 0.7327# 0.2516
  (SD) 0.0080 0.0752 0.1907 0.0824 0.0854 0.1221
  tM 0.7582* 0.8505** 0.3861 0.5867 0.9128** 0.5021
  (SD) 0.1067 0.0591 0.2732 0.0952 0.0793 0.0309
Subiculum PCC 0.582# 0.6819# − 0.0167 − 0.0019 0.7626# 0.1219
  (SD) 0.0942 0.0556 0.0811 0.0989 0.1431 0.0774
  tM 0.6010 0.7563* 0.4915 0.6462 0.9436** 0.4522
  (SD) 0.1824 0.1796 0.1059 0.1177 0.0330 0.1347
Parahippocampal gyrus PCC 0.4842 0.7329# − 0.0699 0.1045 0.8244# 0.1056
  (SD) 0.0405 0.0413 0.0495 0.1657 0.0281 0.1676
  tM 0.7506* 0.8092** 0.4537 0.5529 0.9393** 0.3906
  (SD) 0.0738 0.1445 0.1079 0.0878 0.0410 0.1287
  1. The mean values of Pearson’s correlation coefficients above threshold (PCC) and Manders’ colocalization coefficients above threshold (tM) of FTLD-TDP cases were calculated and plotted by the same method as for the normal controls and presented no large differences from the results in controls (Table 3). For the meaning of the symbols in the table, refer to the explanation in Table 3