Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions

Table 4 Summary of colocalization coefficient values from all evaluated brain regions of the FTLD-TDP cases

Brain regions	Coefficients	Molecules immunolabeled with ATXN2
Brain regions	Coefficients	Calnexin	RPS6	LAMP1	GLG1	PABP1	TDP-43
Temporal cortex	PCC	0.4075	0.7336^#	− 0.2568	0.1767	0.6783^#	0.0027
	(SD)	0.1026	0.0293	0.0715	0.1448	0.1207	0.2457
	tM	0.7545*	0.9126**	0.3935	0.5475	0.872**	0.4817
	(SD)	0.1427	0.0640	0.0560	0.2057	0.0209	0.1394
Hippocampal CA1	PCC	0.4421	0.6949^#	0.1620	0.0542	0.7327^#	0.2516
	(SD)	0.0080	0.0752	0.1907	0.0824	0.0854	0.1221
	tM	0.7582*	0.8505**	0.3861	0.5867	0.9128**	0.5021
	(SD)	0.1067	0.0591	0.2732	0.0952	0.0793	0.0309
Subiculum	PCC	0.582^#	0.6819^#	− 0.0167	− 0.0019	0.7626^#	0.1219
	(SD)	0.0942	0.0556	0.0811	0.0989	0.1431	0.0774
	tM	0.6010	0.7563*	0.4915	0.6462	0.9436**	0.4522
	(SD)	0.1824	0.1796	0.1059	0.1177	0.0330	0.1347
Parahippocampal gyrus	PCC	0.4842	0.7329^#	− 0.0699	0.1045	0.8244^#	0.1056
	(SD)	0.0405	0.0413	0.0495	0.1657	0.0281	0.1676
	tM	0.7506*	0.8092**	0.4537	0.5529	0.9393**	0.3906
	(SD)	0.0738	0.1445	0.1079	0.0878	0.0410	0.1287

The mean values of Pearson’s correlation coefficients above threshold (PCC) and Manders’ colocalization coefficients above threshold (tM) of FTLD-TDP cases were calculated and plotted by the same method as for the normal controls and presented no large differences from the results in controls (Table 3). For the meaning of the symbols in the table, refer to the explanation in Table 3

ISSN: 2051-5960