|
Brain regions
|
Coefficients
|
Molecules immunolabeled with ATXN2
|
|---|
|
Calnexin
|
RPS6
|
LAMP1
|
GLG1
|
PABP1
|
TDP-43
|
|---|
|
Temporal cortex
|
PCC
|
0.4075
|
0.7336#
|
− 0.2568
|
0.1767
|
0.6783#
|
0.0027
|
| |
(SD)
|
0.1026
|
0.0293
|
0.0715
|
0.1448
|
0.1207
|
0.2457
|
| |
tM
|
0.7545*
|
0.9126**
|
0.3935
|
0.5475
|
0.872**
|
0.4817
|
| |
(SD)
|
0.1427
|
0.0640
|
0.0560
|
0.2057
|
0.0209
|
0.1394
|
|
Hippocampal CA1
|
PCC
|
0.4421
|
0.6949#
|
0.1620
|
0.0542
|
0.7327#
|
0.2516
|
| |
(SD)
|
0.0080
|
0.0752
|
0.1907
|
0.0824
|
0.0854
|
0.1221
|
| |
tM
|
0.7582*
|
0.8505**
|
0.3861
|
0.5867
|
0.9128**
|
0.5021
|
| |
(SD)
|
0.1067
|
0.0591
|
0.2732
|
0.0952
|
0.0793
|
0.0309
|
|
Subiculum
|
PCC
|
0.582#
|
0.6819#
|
− 0.0167
|
− 0.0019
|
0.7626#
|
0.1219
|
| |
(SD)
|
0.0942
|
0.0556
|
0.0811
|
0.0989
|
0.1431
|
0.0774
|
| |
tM
|
0.6010
|
0.7563*
|
0.4915
|
0.6462
|
0.9436**
|
0.4522
|
| |
(SD)
|
0.1824
|
0.1796
|
0.1059
|
0.1177
|
0.0330
|
0.1347
|
|
Parahippocampal gyrus
|
PCC
|
0.4842
|
0.7329#
|
− 0.0699
|
0.1045
|
0.8244#
|
0.1056
|
| |
(SD)
|
0.0405
|
0.0413
|
0.0495
|
0.1657
|
0.0281
|
0.1676
|
| |
tM
|
0.7506*
|
0.8092**
|
0.4537
|
0.5529
|
0.9393**
|
0.3906
|
| |
(SD)
|
0.0738
|
0.1445
|
0.1079
|
0.0878
|
0.0410
|
0.1287
|
- The mean values of Pearson’s correlation coefficients above threshold (PCC) and Manders’ colocalization coefficients above threshold (tM) of FTLD-TDP cases were calculated and plotted by the same method as for the normal controls and presented no large differences from the results in controls (Table 3). For the meaning of the symbols in the table, refer to the explanation in Table 3
