Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions

Table 1 Patients examined in this study

Case no.	Age at death (years)	Sex	Brain weight (g)	Postmortem delay (h)	Brain regions	Status of samples	Neuropathological diagnosis
1	72	M	1350	6	F, T, Hip, BG, midbrain	PFA	Cerebral infarct
2	71	M	1180	35	F, T, Hip	PFA, frozen brain	Normal control
3	77	F	1145	9	F, T, Hip	PFA, frozen brain	Normal control
4	72	M	N/A	3.3	F	Frozen brain	Cerebral embolism
5	75	M	1295	24	F	Frozen brain	Cerebral infarct
6	81	M	1240	4.5	F	Frozen brain	Normal control
7	79	M	N/A	3.35	F	Frozen brain	Normal control
8	79	M	N/A	N/A	T	FA	Normal control
9	75	M	1280	6.57	Cerebellum	PFA	Normal control
10	69	F	1145	5	BG, midbrain	PFA	Normal control
11	68	F	1200	37	BG	PFA	Normal control
12	68	M	1220	7	BG	PFA	Normal control
13	73	M	1400	N/A	Midbrain	PFA	Normal control
14	68	F	1160	24	SC	PFA	Normal control
15	68	M	N/A	N/A	T, Hip	PFA	FTLD-TDP type C
16	66	M	N/A	N/A	T, Hip	PFA, frozen brain	FTLD-TDP type C
17	81	M	950	N/A	T, Hip	PFA	FTLD-TDP type C
18	59	M	N/A	N/A	T	Frozen brain	FTLD-TDP type C
19	83	M	1415	19.8	T	Frozen brain	FTLD-TDP type C
20	75	M	1174	N/A	F	Frozen brain	FTLD-TDP type C
21	66	F	1035	N/A	F	Frozen brain	FTLD-TDP type C
22	71	F	955	N/A	F	Frozen brain	FTLD-TDP type A

F frontal cortex, T temporal cortex, Hip hippocampal region, FA formaldehyde-fixed brain sections, PFA paraformaldehyde-fixed brain sections, FTLD frontotemporal lobar degeneration, BG basal ganglia, SC spinal cord

ISSN: 2051-5960