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Table 3 Comparison of patients whose tumors exhibited temporal genomic heterogeneity (n = 12) and patients whose tumors had completely conserved genomic profiles (n = 33)

From: Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas

  Patients whose tumors had temporal genomic heterogeneity Patients whose tumors did not have temporal genomic heterogeneity p value
n 12 33
Age at diagnosis [median (Range) in years] 5.8 (0.4–15.7) 6.1 (0.8–18.3) 0.70
Received systemic therapy and/or irradiation between surgeries [n (%)] 6 (50%) 14 (42%) 0.30
WHO grade I [n (%)]a 10 (91%) 24 (73%) 0.66
  1. Statistics were performed using the Wilcoxon Rank-Sum test for differences in age, and using Fischer’s Exact test for differences in the proportions who received interval systemic therapy and/or irradiation and for WHO grade (I versus II) histology, with p-value < 0.05 considered significant
  2. aExcluding patients with tumors of indeterminate WHO grading [pilomyxoid astrocytoma or low grade neoplasm (unclear if WHO grade I versus II)]