Skip to main content

Table 3 Comparison of patients whose tumors exhibited temporal genomic heterogeneity (n = 12) and patients whose tumors had completely conserved genomic profiles (n = 33)

From: Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas

 

Patients whose tumors had temporal genomic heterogeneity

Patients whose tumors did not have temporal genomic heterogeneity

p value

n

12

33

–

Age at diagnosis [median (Range) in years]

5.8 (0.4–15.7)

6.1 (0.8–18.3)

0.70

Received systemic therapy and/or irradiation between surgeries [n (%)]

6 (50%)

14 (42%)

0.30

WHO grade I [n (%)]a

10 (91%)

24 (73%)

0.66

  1. Statistics were performed using the Wilcoxon Rank-Sum test for differences in age, and using Fischer’s Exact test for differences in the proportions who received interval systemic therapy and/or irradiation and for WHO grade (I versus II) histology, with p-value < 0.05 considered significant
  2. aExcluding patients with tumors of indeterminate WHO grading [pilomyxoid astrocytoma or low grade neoplasm (unclear if WHO grade I versus II)]