Fig. 2
From: Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas
Histologic and molecular findings in paired samples from representative patients. a The pilocytic astrocytoma from Patient #18 retained a BRAF fusion. Note that the partial duplication of 3′BRAF (7q34) b is most commonly associated with the BRAF-KIAA1549 fusion product. c The ganglioglioma from Patient #40 retained a BRAFV600E mutation (d BRAF V600E IHC, 400x). e The pilocytic astrocytoma from Patient #2 acquired a hemizygous deletion (loss of one copy) of CDKN2A (f), while the diffuse astrocytoma (g) from Patient #33 lost this alteration (h). (2A, E, and G, H&E x100; 2C, x200)