Fig. 1

Genomic profiles of paired primary and recurrent and/or progressive tumor samples from 45 pediatric patients with LGGs analyzed in this study, grouped by histopathologic classification. Patients’ age (years), sex, tumor location, treatment received between primary and subsequent surgeries (systemic therapy [“S”], irradiation [“I”], or both [“B”]), and time interval (months) between respective surgeries are indicated. Each row of circles represents a tumor pair (or triplet) from an individual patient. The left half of a circle represents the primary diagnostic tumor sample, the right half represents the second subsequent surgical sample, and a third semicircle (with *) represents a third surgical sample if applicable. Dark blue, dark gray, and light blue semi-circles indicate positivity, negativity, or testing not able to be performed for the given genetic alteration, respectively