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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms

Fig. 2

M120I and R533* mutations impair the C-terminal protein interactions of CTTNBP2. Co-immunoprecipitation (IP) using transfected COS1 cell lysates was performed to analyze the protein–protein interactions of seven ASD-linked mutations of CTTNBP2. a The interactions between HA-tagged WT CTTNBP2 and Myc-tagged ASD mutants. b The interaction between Myc-tagged cortactin and various HA-tagged CTTNBP2 constructs from transfected COS1 cells. Myc tag mouse antibody was used for IP, and both Myc and HA antibodies (from rabbit and rat, respectively) were used for immunoblotting, as indicated

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Acta Neuropathologica Communications

ISSN: 2051-5960

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