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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Mild hypoxia triggers transient blood–brain barrier disruption: a fundamental protective role for microglia

Fig. 6

Levels of hypoxia-induced endothelial proliferation are region-specific. a Frozen brain sections taken from mice exposed to hypoxia (8% O2) for 4 days were stained for CD31 (AlexaFluor-488) and the proliferation marker Ki67 (Cy-3). Images were captured in the brainstem, olfactory bulb, cerebral cortex, and cerebellum. Scale bar = 100 μm. b Quantification of the number of proliferating endothelial cells (CD31 + /Ki67 + cells)/FOV. Results are expressed as the mean ± SEM (n = 4 mice/group). *p < 0.05; **p < 0.01. Note that hypoxia-induced endothelial proliferation was significantly higher in the brainstem and olfactory bulb versus the cerebral cortex and cerebellum

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