Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy

Table 4 Quantitative tau neuropathology trait associations in PSP

SNP	Tau traits tested	N	Genotype counts	BETA	p	95% CI
ABI3 rs616338	CB	840	0/19/821	0.057	0.773	− 0.333 to 0.448
	NFT	840	0/19/821	0.382	0.064	− 0.022 to 0.786
	TA	840	0/19/821	− 0.096	0.649	− 0.511 to 0.318
	TAUTH	840	0/19/821	0.204	0.317	− 0.195 to 0.603
	Overall	840	0/19/821	0.187	0.400	− 0.248 to 0.622
PLCG2 rs72824905	CB	841	0/14/827	− 0.487	0.035	− 0.938 to − 0.036
	NFT	841	0/14/827	− 0.449	0.060	− 0.916 to 0.018
	TA	841	0/14/827	− 0.482	0.049	− 0.96 to − 0.004
	TAUTH	841	0/14/827	− 0.546	0.020	− 1.006 to − 0.085
	Overall	841	0/14/827	− 0.638	0.013	− 1.139 to − 0.136

Nominally significant p values < 0.05 are shown in bold
Results of multivariable linear regression using the additive model for association of ABI3_rs616338-T and PLCG2_rs72824905-G with neuropathologic traits in autopsied PSP subjects. All analyses adjust for sex and age
CI confidence interval. Genotypes for ABI3(rs616338)-(TT/CT/CC) and PLCG2(rs72824905)-(GG/CG/CC). Neuropathology traits: CB oligodendroglial coiled bodies, NFT neurofibrillary tangles, TA tufted astrocytes, TAUTH Tau neurophil threads

ISSN: 2051-5960