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Table 4 Quantitative tau neuropathology trait associations in PSP

From: Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy

SNP Tau traits tested N Genotype counts BETA p 95% CI
ABI3 rs616338 CB 840 0/19/821 0.057 0.773 − 0.333 to 0.448
NFT 840 0/19/821 0.382 0.064 − 0.022 to 0.786
TA 840 0/19/821 − 0.096 0.649 − 0.511 to 0.318
TAUTH 840 0/19/821 0.204 0.317 − 0.195 to 0.603
Overall 840 0/19/821 0.187 0.400 − 0.248 to 0.622
PLCG2 rs72824905 CB 841 0/14/827 − 0.487 0.035 − 0.938 to − 0.036
NFT 841 0/14/827 − 0.449 0.060 − 0.916 to 0.018
TA 841 0/14/827 − 0.482 0.049 − 0.96 to − 0.004
TAUTH 841 0/14/827 − 0.546 0.020 − 1.006 to − 0.085
Overall 841 0/14/827 − 0.638 0.013 − 1.139 to − 0.136
  1. Nominally significant p values < 0.05 are shown in bold
  2. Results of multivariable linear regression using the additive model for association of ABI3_rs616338-T and PLCG2_rs72824905-G with neuropathologic traits in autopsied PSP subjects. All analyses adjust for sex and age
  3. CI confidence interval. Genotypes for ABI3(rs616338)-(TT/CT/CC) and PLCG2(rs72824905)-(GG/CG/CC). Neuropathology traits: CB oligodendroglial coiled bodies, NFT neurofibrillary tangles, TA tufted astrocytes, TAUTH Tau neurophil threads