Fig. 6
From: A novel recessive mutation affecting DNAJB6a causes myofibrillar myopathy
Changes in fiber type composition of tibialis anterior and gastrocnemius muscles in 12-month-old HOM and WT mice. a, b Representative transverse sections of tibialis anterior (TA) (a) and gastrocnemius (GSN) (b) muscles from 12-month-old WT and HOM mice immunostained with fiber type-specific myosin heavy chain antibodies. Scale bar: 200 µm. Note the decrease in proportion of type IIA fibers and increase in type IIB fibers in the TA from HOM mice (a), and the decrease in type I fibers in parallel with an increase in type IIB fibers in the GSN from HOM mice (b). c, d Quantified fiber type distribution by percent of total in individual fiber types. Values are expressed as mean ± SEM (n = 3). P value = * < 0.05, ** < 0.01