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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Nilvadipine suppresses inflammation via inhibition of P-SYK and restores spatial memory deficits in a mouse model of repetitive mild TBI

Fig. 7

Representative images of GFAP, P-SYK and Iba1 in corpus callosum. No sham animals showed reactive astrocytes, microgliosis or signs of P-SYK. In the r-mTBI-vehicle mice, microglia appear to acquire amoeboid morphology and colocalize with P-SYK accumulations. Treatment with nilvadipine or ARC031 also eliminated detection of P-SYK in the corpus callosum in the areas near Iba1-reactive microglia. Distribution (M-male, F-female): sham-vehicle n = 10 (5M, 5F), r-mTBI-vehicle n = 12 (6M, 6F), sham-nilvadipine n = 11 (5M, 6F), r-mTBI-nilvadipine n = 10 (5M, 5F), sham-ACR031 n = 8 (4M, 4F), r-mTBI-ARC031 n = 7 (3M, 4F). Scale bars equal 10 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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