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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Nilvadipine suppresses inflammation via inhibition of P-SYK and restores spatial memory deficits in a mouse model of repetitive mild TBI

Fig. 5

a–b Effects of nilvadipine on microglia in the r-mTBI mice. After r-mTBI, Iba1 signal was increased in the CC compared to sham-vehicle (\(p<0.01\)). A significant decrease of Iba1 was shown in the r-mTBI mice after treatment with nilvadipine (\(p<0.05\)) and ARC031 (\(p<0.01\)). Distribution (M-male, F-female): sham-vehicle n = 5 (2M, 3F), r-mTBI-vehicle n = 5 (1M, 4F), sham-nilvadipine n = 5 (3M, 2F), r-mTBI-nilvadipine n = 6 (4M, 2F), sham-ACR031 n = 4 (2M, 2F), r-mTBI-ARC031 n = 7 (5M, 2F). Data were analyzed using one-way ANOVA. Scale bars equal 20 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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