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Table 1 Population characteristics of primary and first recurrence tumors

From: Homozygous deletion of CDKN2A by fluorescence in situ hybridization is prognostic in grade 4, but not grade 2 or 3, IDH-mutant astrocytomas

Primary tumors (n = 108)

Histologic grade 2 (n = 55)

Histologic grade 3 (n = 31)

Histologic grade 4 (n = 22)

Mean age at presentation (Years)

38.9 (19–77)

36.8 (22–79)

40.8 (23–56)

Sex (M/F)

26/29

15/16

13/9

Average length of available follow-up* (months)

65.6 (1.45–175.5)

70.5 (3.7–186.9)

44.3 (4.5–112.9)

Mean percent cells with homozygous CDKN2A deletion

5.00 (0–40)

8.40 (0–37.1)

23.0 (0–93.8)

First recurrence tumors (n = 35)

Histologic grade 2 (n = 8)

Histologic grade 3 (n = 13)

Histologic grade 4 (n = 14)

Mean age at recurrence

44.1 (35–58)

42 (28–64)

39.9 (28–57)

Sex (M/F)

5/3

7/6

11/3

Received adjuvant chemotherapy and/or radiation (percent)

4/8 (50%)

12/13 (92%)

14/14 (100%)

Mean duration between primary and first recurrent resection (months)

58.5 (2.5–241.6)

79.1 (12.0–184.5)

59.6 (4.8–153.1)

Average length of follow-up after recurrence (months)

65.3 (31.1–118.3)

27.6 (1.3–94.3)

18.2 (0.9–71.1)

Mean percent cells with homozygous CDKN2A deletion

3.2 (0–13)

24.3 (0–92.0)

53.9 (1.6–95.6)

  1. *These values do not include 5 patients for whom no clinical follow-up was available