Skip to main content

Table 1 Population characteristics of primary and first recurrence tumors

From: Homozygous deletion of CDKN2A by fluorescence in situ hybridization is prognostic in grade 4, but not grade 2 or 3, IDH-mutant astrocytomas

Primary tumors (n = 108) Histologic grade 2 (n = 55) Histologic grade 3 (n = 31) Histologic grade 4 (n = 22)
Mean age at presentation (Years) 38.9 (19–77) 36.8 (22–79) 40.8 (23–56)
Sex (M/F) 26/29 15/16 13/9
Average length of available follow-up* (months) 65.6 (1.45–175.5) 70.5 (3.7–186.9) 44.3 (4.5–112.9)
Mean percent cells with homozygous CDKN2A deletion 5.00 (0–40) 8.40 (0–37.1) 23.0 (0–93.8)
First recurrence tumors (n = 35) Histologic grade 2 (n = 8) Histologic grade 3 (n = 13) Histologic grade 4 (n = 14)
Mean age at recurrence 44.1 (35–58) 42 (28–64) 39.9 (28–57)
Sex (M/F) 5/3 7/6 11/3
Received adjuvant chemotherapy and/or radiation (percent) 4/8 (50%) 12/13 (92%) 14/14 (100%)
Mean duration between primary and first recurrent resection (months) 58.5 (2.5–241.6) 79.1 (12.0–184.5) 59.6 (4.8–153.1)
Average length of follow-up after recurrence (months) 65.3 (31.1–118.3) 27.6 (1.3–94.3) 18.2 (0.9–71.1)
Mean percent cells with homozygous CDKN2A deletion 3.2 (0–13) 24.3 (0–92.0) 53.9 (1.6–95.6)
  1. *These values do not include 5 patients for whom no clinical follow-up was available
\