Primary tumors (n = 108) | Histologic grade 2 (n = 55) | Histologic grade 3 (n = 31) | Histologic grade 4 (n = 22) |
---|---|---|---|
Mean age at presentation (Years) | 38.9 (19–77) | 36.8 (22–79) | 40.8 (23–56) |
Sex (M/F) | 26/29 | 15/16 | 13/9 |
Average length of available follow-up* (months) | 65.6 (1.45–175.5) | 70.5 (3.7–186.9) | 44.3 (4.5–112.9) |
Mean percent cells with homozygous CDKN2A deletion | 5.00 (0–40) | 8.40 (0–37.1) | 23.0 (0–93.8) |
First recurrence tumors (n = 35) | Histologic grade 2 (n = 8) | Histologic grade 3 (n = 13) | Histologic grade 4 (n = 14) |
---|---|---|---|
Mean age at recurrence | 44.1 (35–58) | 42 (28–64) | 39.9 (28–57) |
Sex (M/F) | 5/3 | 7/6 | 11/3 |
Received adjuvant chemotherapy and/or radiation (percent) | 4/8 (50%) | 12/13 (92%) | 14/14 (100%) |
Mean duration between primary and first recurrent resection (months) | 58.5 (2.5–241.6) | 79.1 (12.0–184.5) | 59.6 (4.8–153.1) |
Average length of follow-up after recurrence (months) | 65.3 (31.1–118.3) | 27.6 (1.3–94.3) | 18.2 (0.9–71.1) |
Mean percent cells with homozygous CDKN2A deletion | 3.2 (0–13) | 24.3 (0–92.0) | 53.9 (1.6–95.6) |