Skip to main content
Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Homozygous deletion of CDKN2A by fluorescence in situ hybridization is prognostic in grade 4, but not grade 2 or 3, IDH-mutant astrocytomas

Fig. 3

A cutoff of ≥ 30% homozygous deletion by FISH maximizes the prognostic value of CDKN2A in IDHm astrocytomas. Cox-PH models were constructed using a range of CDKN2A cutoff values from 5 to 35%, as well as sex, age, and histologic grade. At each cutoff, the partial AIC value, hazard ratios, and p-values of the model fit for each parameter were assessed. Models were constructed independently for primary tumors (a) and first recurrences (b). For primary tumors, the hazard ratio (middle row, orange line) and statistical significance (bottom row, orange line) of CDKN2A deletion are maximized and the AIC (top row, black line) is minimized at a cutoff of ≥ 30%, indicating optimal model characteristics. For first recurrence tumors, cutoffs between 25–35% perform equally across the three measures. Varying the CDKN2A cutoff does not substantially influence the hazard ratio or significance of histologic grade as an independent prognostic variable (middle and bottom rows, blue lines)

Back to article page
\