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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Homozygous deletion of CDKN2A by fluorescence in situ hybridization is prognostic in grade 4, but not grade 2 or 3, IDH-mutant astrocytomas

Fig. 1

High percentage CDKN2A homozygous deletion is a rare event in primary IDHm astrocytomas and is more common in recurrent tumors. a shows the frequency distribution of the percent of tumor cells with homozygous CDKN2A deletion by FISH in primary IDHm astrocytomas (n = 108). Very few tumors have high-percentage homozygous deletion, and the majority of the tumors with high-percentage deletion are morphologic grade 4. b shows the frequency distribution in recurrent tumors (n = 43). High-percentage deletion is a more frequent event in recurrent tumors and is seen in both histologic grades 3 and 4

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