Targeted deletions of complement lectin pathway genes improve outcome in traumatic brain injury, with MASP-2 playing a major role

Table 1 Summary table

Strain	1 week		2 week		3 week		4 week
Strain	% of WT	p value	% of WT	p value	% of WT	p value	% of WT	p value
MASP-2^−/−
Neuroscore	+ 11.4	0.6079	+ 4.3	0.9605	+ 13.6	0.4541	− 5.9	0.8809
Beam Walk	+ 5.5	0.9608	+ 27.9	0.0681	+ 32.1	0.0202	+ 36	0.0091
MBL^−/−
Neuroscore	+ 33.7	0.0997	+ 42.8	0.0023	+ 37.2	0.0011	+ 35.6	0.0003
Beam Walk	+ 12.9	0.2972	+ 24.03	0.0131	+ 25.1	0.0133	+ 21.4	0.0742
FCN-A^−/−
Neuroscore	+ 19.7	0.9253	+ 0.37	> 0.9999	− 7.9	0.7784	+ 5.3	0.9171
Beam Walk	+ 6.7	0.9253	+ 15	0.5412	+ 13	0.685	+ 9.9	0.829
CL-11^−/−
Neuroscore	+ 16	0.4086	+ 13.5	0.5552	+ 11.2	0.631	+ 11.9	0.5552
Beam Walk	− 4.9	0.8735	+ 11.1	0.3198	+ 15.8	0.0711	+ 23.5	0.0024
MBL-C^−/−
Neuroscore	+ 10	> 0.9999	+ 2.9	> 0.9999	+ 11.1	> 0.9999	− 16.7	0.8796
Beam Walk	− 3.5	> 0.9999	− 3.5	> 0.9999	3.6	> 0.9999	+ 3.9	> 0.9999
MASP-1/3^−/−
Neuroscore	+ 9.1	0.9426	+ 11.9	0.784	+ 8.7	0.8759	− 1.9	0.9976
Beam Walk	+ 1.07	0.9997	+ 0.56	> 0.9999	− 2.6	0.997	0	> 0.9999
MBL-A^−/−
Neuroscore	+ 4.5	0.9986	+ 7.1	0.989	− 2.9	0.9986	− 19.5	0.589
Beam Walk	− 10	0.9025	− 4.2	0.9932	− 9.8	0.9133	− 11.01	0.8786

Summary of the outcome measures in the MASP-2^−/−, MBL^−/−, FCN-A^−/−, CL-11^−/−, MBL-C^−/−, MASP-1/3^−/− or MBL-A^−/− TBI mice. For MBL^−/−, data were obtained from the previous paper by Longhi et al. [32]

ISSN: 2051-5960