Fig. 1

Experimental design. a WT or KOs mice (including: MASP-2^−/−, MBL^−/−, FCN-A^−/−, CL-11^−/−, MBL-C^−/−, MASP-1/3^−/− and MBL-A^−/−) were subjected to TBI or sham injury. Sensorimotor deficits were assessed weekly by neuroscore and beam walk test. The sum of 4-week performances of each mouse genotype has been used to calculate the health score. b MBL brain presence and residual LP activity in plasma was assed in MASP-2^−/− and WT TBI mice 30′ after surgery. Histopathological analysis was done for MASP-2^−/− and WT mice at 6 weeks after TBI