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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD

Fig. 6

Overexpression of UBQLN1 reduces UBQLN2 inclusions and ER stress in the spinal cord. a Immunofluorescence staining of the sections in the ventral horn region of the spinal cord for UBQLN2 and DAPI and of their combined staining. b Quantification of the number of UBQLN2 inclusions based on size in the spinal cord of the four genotypes at 52 weeks of age (2 males and 1 female for each genotype). *P < 0.05, **P < 0.01. c Immunoblots of SC lysates for the different genotypes probed for the proteins shown. d Quantification of changes in phospho-eIF2α after normalizing for expression of total eIF2α protein (2 males and 1 female for each genotype). **P < 0.01

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