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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD

Fig. 5

Neuronal loss in the hippocampus induced by overexpression of the P497S mutant UBQLN2 protein is partially rescued by UBQLN1 overexpression. a Representative examples of NeuN staining of the hippocampus regions for the different genotypes at 52 weeks of age. b Stereology neuron counts contained in similar size areas of the DG and CA1 regions of hippocampus for the different genotypes (2 males and 1 female for each genotype except the double Tg where 3 males were used). The reduction of neurons in the CA1 regions of P497S was close to significant (P = 0.07). **P < 0.01

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