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Table 2 Mendelian randomization analysis of the association between longer LTL score and ependymoma risk in CCRLP, Toronto, and GICC case–control datasets

From: Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma

MR Estimate Pediatric EPN-PF-A (Toronto)a Childhood-onsetb (CCRLP) Adolescent-onsetc (CCRLP) Adult-onsetd (GICC)
OR (95% CI) P-value OR (95% CI) P-value OR (95% CI) P-value OR (95% CI) P-value
IVW 0.51 (0.03, 8.7) 0.64 0.93 (0.15, 5.7) 0.94 91.7 (3.6, 2.3 × 103) 0.0063 2.01 (0.34, 12.0) 0.43
Weighted median 0.61 (0.03, 13.3) 0.76 0.82 (0.08, 7.9) 0.85 368 (4.1, 3.3 × 104) 0.010 2.82 (0.27, 29.0) 0.38
Mode-based 0.67 (0.02, 22.5) 0.82 0.30 (0.02, 4.9) 0.40 690 (0.42, 1.1 × 106) 0.084 4.05 (0.30, 4.01) 0.30
MR Egger 183 (1.0 × 10−6, 3.3 × 1010) 0.59 0.08 (2.8 × 10−4, 23.1) 0.38 793 (0.02, 3.2 × 107) 0.22 294 (1.23, 7.0 × 104) 0.042
(Intercept) 0.61 (0.13, 2.94) 0.45 1.19 (0.81, 1.8) 0.37 0.86 (0.43, 1.7) 0.67 0.70 (0.48, 1.01) 0.059
  1. Adjusted for subject sex and 10 ancestry-informative principal components
  2. Nominally significant P values < 0.05 in bold
  3. aSample size for Toronto posterior fossa type A pediatric ependymoma case–control study includes 83 cases and 332 controls
  4. bSample size for CCRLP childhood-onset case–control subset includes 114 cases (age < 12 years) and 696 controls
  5. cSample size for CCRLP adolescent-onset case–control subset includes 39 cases (age 12–19 years) and 696 controls
  6. dSample size for Glioma International Case-Control Consortium (GICC) case–control study includes 103 cases (ages 18+) and 3287 controls