Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma

Table 1 Association between a polygenic score for longer telomere length and risk of ependymoma in the California Cancer Record Linkage Project case–control dataset (ages 0–19)

Logistic regression model	Cases/controls	OR (95% CI)^a	P-value
All patients combined	153/696	1.12 (0.94–1.34)	0.207
Childhood-onset^c	114/696	0.99 (0.81–1.21)	0.939	P_case-case = 0.021^b
Adolescent-onset^d	39/696	1.67 (1.18–2.37)	3.97 × 10⁻³	P_case-case = 0.021^b

Nominally significant P values < 0.05 in bold
^aAdjusted for sex and 10 principal components
^bP-value corresponding to the association between a polygenic score for longer telomere length and age at diagnosis (< 12 vs. ≥ 12) in a case-only analysis of ependymoma patients
^cless than 12 years of age at diagnosis
^d12–19 years of age at diagnosis

ISSN: 2051-5960