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Table 3 Correlation of levels of soluble and insoluble poly-GP, poly-GA and poly-GR with parameters of clinical severity (age at death, age of onset, disease duration)

From: Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity

 

Poly-GP

Poly-GA

Poly-GR

Soluble

Insoluble

Soluble

Insoluble

Soluble

Insoluble

Age at death

FC

− 0.44

− 0.42

− 0.22

− 0.22

− 0.14

− 0.72 (0.007)

TC

− 0.48 (0.10)

− 0.27

− 0.03

0.02

− 0.51 (0.08)

− 0.61 (0.03)

OC

− 0.40

− 0.14

0.44

0.27

− 0.53 (0.07)

− 0.54 (0.06)

Cb

− 0.08

− 0.11

− 0.05

− 0.22

− 0.01

− 0.12

Age of onset

FC

− 0.45

− 0.34

− 0.49 (0.09)

− 0.39

− 0.06

− 0.53 (0.07)

TC

− 0.60 (0.03)

− 0.38

− 0.11

− 0.20

− 0.52 (0.07)

− 0.55 (0.06)

OC

− 0.48 (0.10)

− 0.17

0.26

0.17

− 0.47 (0.10)

− 0.45

Cb

− 0.16

− 0.23

0.08

− 0.41

0.15

− 0.12

Disease duration

FC

− 0.19

− 0.50 (0.09)

0.35

0.08

− 0.48 (0.10)

− 0.66 (0.02)

TC

− 0.08

0.08

0.23

0.36

− 0.49 (0.09)

− 0.64 (0.02)

OC

− 0.12

− 0.06

0.44

0.17

− 0.34

− 0.52 (0.07)

Cb

0.21

0.33

− 0.08

0.23

− 0.26

0.12

  1. Spearman’s rank correlation coefficient ρ is shown for correlation of soluble and insoluble poly-GP, poly-GA and poly-GR in frontal cortex (FC), temporal cortex (TC), occipital cortex (OC) and cerebellum (Cb) with age at death, age of onset and disease duration. Correlation coefficients with statistical significance are shown in bold. For all values showing a statistically significant or a trend of correlation, p-values are specified between brackets