Fig. 4

Insoluble poly-GR levels correlate with clinical parameters. Correlation of insoluble poly-GR levels in frontal and temporal cortex with age at death (a–b) and disease duration (c–d). The data points in the graphs represent individual C9orf72 cases (with homozygous C9orf72 mutation case in red). Spearman’s correlation analysis performed with Spearman’s correlation coefficient ρ. All data are shown in Table 3