Fig. 2

DPR protein concentrations across different brain regions. Soluble (a–c) and insoluble (d–f) poly-GP, poly-GA and poly-GR levels are depicted across frontal cortex (FC), temporal cortex (TC), occipital cortex (OC) and cerebellum (Cb). The homozygous C9orf72 mutation case is shown in red. All data are mean ± SEM. Statistical analysis: Friedman test followed by Dunn’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001